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Sep 2014;22(3):155-164

S-adenosyl methionine (SAMe) versus escitalopram and placebo in major depression RCT: Efficacy and effects of histamine and carnitine as moderators of response

Moreover, studies have shown that certain drugs and integrative interventions, such as the staple antidiabetic medication metformin and the turmeric compound curcumin, may help overcome chemoresistance and sensitize some cancers to the toxic effects of chemotherapy

Interestingly with Chen et al, it was noted that those reported improvement had low urinary nitrite/nitrate, the excreted metabolic products of NO, suggesting that those with low NO levels are more likely to improve with L-arginine supplementation