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Future efforts aim to optimize antigen targeting, increase mRNA stability, enhance homing to the TME, and expand clinical trials to assess effectiveness across different cancer types [21]

By upregulating enzymes such as medium-chain acyl-CoA dehydrogenase (MCAD) and mitochondrial pyruvate carrier 1 (MPC1), ERR promotes the uptake and oxidation of fatty acids, providing acetyl-CoA for the tricarboxylic acid (TCA) cycle, which in turn drives mitochondrial ATP production

Interestingly, walking around and using the legs seems to override these symptoms, and the condition comes to awareness only when body weight has been removed from the legs when sitting or reclining

Hameed, M., et al