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conducted a 20-year investigation into the link between occupational heavy metal exposure and PD and found an individual with chronic copper exposure had a two-and-a-half-fold increased risk of PD [Odds Ratio [OR] 2.49, 95% CI 1.065.89] (65)

For example, taking very high doses of vitamin B6 can lead to potentially irreversible nerve damage over time, while taking large amounts of niacin typically in excess of 2 grams per day can cause liver damage ( Fat-soluble vitamins Unlike water-soluble vitamins, fat-soluble vitamins do not dissolve in water and are easily stored in your bodys tissues ( There are four fat-soluble vitamins: Vitamin A Vitamin D Vitamin E Vitamin K Given that fat-soluble vitamins can accumulate in the body, these nutrients are more likely to lead to toxicity than water-soluble vitamins

the most likely explanation is poor oral bioavailability at the doses tested, though no official statement was made

Furthermore, female patients with hepatolenticular degeneration (HLD) often experience reproductive dysfunction (Roseira et al., 2022