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FIGURE 2 However, in sepsis mice, it has been observed that the activation of the TLR4/ATF/CHOP signaling pathway by ER stress can induce apoptosis or dysfunction in Panzer cells, leading to exhaustion and subsequently impairing intestinal stem cell mobility, reducing secretion of antimicrobial peptides, exacerbating intestinal injury, and ultimately increasing mortality (Wang et al., 2022)

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While different studies have shown the inverse association between IL-6, TNF-, CRP, and serum zinc levels in adults aged 40 [36]