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Interim analyses of a first-in-human phase 1/2 mRNA trial for propionic acidaemia

A crosstalk between the different peripheral immune cells and the glia residing in CNS, as showed in Figure 4 , is necessary for sustaining inflammation and demyelination within lesions

First, the hierarchical coordination between distinct lipid metabolic pathways (e.g., ACSL4-LPCAT3-mediated PUFA esterification vs

It has been speculated that changes in the content of PL and DAG, as well as the redistribution of fatty acids of various lipid fractions, have an effect on the protein lipid relationships and the orderliness of fatty acids (viscosity) in the myelin and axolemma of the nerve fiber [124]