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doi: 10.1016/j.pediatrneurol.2012.09.014 46

2013;14(9):e370379

4.2.4 Bidirectional crosstalk between ferroptosis and TME Ferroptosis-generated heme/ATP activates the DC-STING-IFN- pathway, reversing the TME from a TGF-/adenosine-driven suppressive state to an inflammatory immune-permissive state by blocking SLC7A11 depletion of Treg/MDSC GSH reserves and eliminating immunosuppressive neutrophils

Corticosteroids: Powerful anti-inflammatory drugs that can suppress the immune system and lead to severe systemic side effects if taken orally without medical supervision