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Acquired Risk Factors (13): Immobilization for prolonged periods (example: bed rest greater than 3 days, any travel for greater than 4 hours) Recent orthopedic surgery Hip or knee replacement Fracture of a lower limb Major trauma Malignancy (highest risk with metastatic disease) Chemotherapy Indwelling venous catheter Obesity Pregnancy/ postpartum period Cigarette smoking also poses an increased risk for pulmonary infarction from pulmonary embolism

These cases have had a very aggressive disease course and have been fatal