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(c) nuclear translocation of predominantly p65/p50 dimers to induce transcription of target genes, including well-established FLICE-like inhibitory protein (c-FLIP) and apoptosis protein inhibitors (c-IAP)

It manifests not only as increased wrinkles, reduced elasticity, and pigmentation but also as impaired epidermal barrier function and immune dysregulation, thereby increasing the risk of degenerative diseases such as atopic dermatitis and xerosis cutis