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It was confirmed that NNMT knockdown contributes to significant suppression of cell proliferation and anchorage-independent cell growth in vitro and in vivo (61)

Ultimately, protoporphyrin ferrochelatase (PpfC) catalyzes the insertion of Fe 2+ into protoporphyrin IX to produce heme

The dosing information for methyl cobalamin injection may vary depending on the individual's age, weight, medical history, and the condition being treated

Erastin, one of the earliest discovered ferroptosis inducers, inhibits system Xc - (SLC7A11/SLC3A2), thereby impairing GSH synthesis, leading to ROS accumulation and inducing GBM cell death ( 2+ levels, increased GSH levels, and suppressed expressions of ferroptosis-related proteins such as GPX4, NRF2, and SLC7A11 ( RAS-selective lethal 3 (RSL3) is a known ferroptosis inducer