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Catechol-O-methyltransferase inhibition with entacapone: evidence from controlled clinical trials in Parkinsons disease

FIGURE 3 6 Tumor microenvironment and redox homeostasis The tumor microenvironment comprises tumor cells, stromal cells, immune cells, secretory products (such as cytokines and chemokines) of corresponding cells, and non-cellular components in the extracellular matrix (ECM), which are closely related to tumor growth and metastasis

Furthermore, when methionine is deprived, the endogenous methionine in cancer cells is preferentially used for protein synthesis

The amino acid residues that make up the H-site are involved in recognizing and binding various exogenous and endogenous compounds and positioning their electrophilic centers for attack by the nucleophilic GSH