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In cartilage research, a 2015 study in a collagenase-induced knee osteoarthritis rabbit model showed that combined AOD-9604 and hyaluronic acid injections were significantly more effective than either treatment alone, with treated groups showing lower gross morphological and histopathological scores

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The "right" dose sits in a narrow window that depends on: Delivery method - injectable GHK-Cu vs topical GHK-Cu vs oral/sublingual GHK-Cu Goal - skin rejuvenation , hair and scalp support, wound healing , general anti-ageing Individual factors - age , skin type , baseline GHK levels , other peptides being stacked Natural plasma GHK falls from roughly 200 ng/ml at age 20 to around 80 ng/ml by age 60