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It solely affects the mucosa ( An increasing amount of evidence derived from both clinical investigations and experimental models indicates that oxidative stress signaling contributes to the development of IBD through various functional pathways

Foveolar thickness decreased in 56% of patients (p 3 lines in 50% of eyes after 1 month and in 42% of eyes at last follow up.8 eyes developed recurrent ME at an average of 5.5 months after initial TA injection.Cheng et al.107Prospective nonrandomized interventional comparative study.16 eyes (4 mg TA)

It is caused by variations in the ATP8B1 gene, which encodes transmembrane lipid transporter proteins located in the membrane

Pharmacokinetics Diclofenac: The absorption starts immediately after administration