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( A ) Area under the luminescence curve obtained after pretreating APEX2 expressing HeLa cells with the indicated concentrations of Na 2 S (left panel) or 3MP (right panel) for 5 min before the addition of H 2 O 2 (50 M)

In the context of IRI, diminished tissue perfusion during the ischemic phase leads to enhanced anaerobic glycolysis and subsequent lactate accumulation

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elegans strains (wild type and mutants) used in this study are listed in Supplementary Table 1