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doi: 10.3390/ijms24097910

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Nrf2 orchestrates redox homeostasis by inducing genes encoding GPX4, FTH1, NQO1, and HO-1, thereby stabilizing GSH pools, suppressing lipid peroxidation, and modulating iron and mitochondrial metabolism (150 N -Acetylcysteine rescues Sirt3SOD2/GPX4 signaling, attenuating renal ferroptosis ( 3.3.6 Natural compounds and TCM intervention in intervening ferroptosis in DN Numerous studies have reported that active components of traditional Chinese medicine (TCM) (186) can ameliorate renal injury and ferroptosis in DN by activating antioxidant proteins