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[21] [22] Clinical significance [edit] Patients with mutations in the GSS gene develop glutathione synthetase (GSS) deficiency, an autosomal recessive disorder

Hematoxylin and eosin (HE) staining revealed that DON treatment impaired ovarian health, leading to follicular atresia and nuclear pyknosis, which were alleviated by melatonin supplementation (Supplementary Fig

So, to develop new therapies to lessen the effects of CP-induced ovarian damage, further studies are needed to assess other signaling molecular pathways that may be involved