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Retinoids: Tretinoin, one of the types of retinoids, improves the rate of skin cell shedding and can gradually reduce the darkness of the spots

This concept is directionally consistent with reports of elevated marginal bone levels in clinical case-series observations [144] and with randomized controlled evidence suggesting a more favorable interfacial bone structure after osseointegration [135]

These findings emphasize that oxidative phosphorylation is not only disrupted by hyperglycemia but also acts as a sustained source of ROS that drives retinal cell injury

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