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and (b) allowing a CRISPR complex to bind to a target polynucleotide to effect cleavage of the target polynucleotide within said disease gene, wherein the CRISPR complex comprises the CRISPR enzyme complexed with (1) the guide sequence that is hybridized to the target sequence within the target polynucleotide, and (2) the tracr mate sequence that is hybridized to the tracr sequence, thereby generating a model eukaryotic cell comprising said cleavage comprises cleaving one or two strands at the location of the target sequence by said CRISPR enzyme

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Learn more SS-31 Peptide Therapy SS-31 (elamipretide) is a mitochondria-targeted peptide that binds cardiolipin in the inner mitochondrial membrane, where it may support the cellular energy production that declines with age and oxidative stress