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20 While there are various types of Bregs, these studies show many ways that tissue-resident Bregs can enact similar mechanisms to promote tolerogenic responses by secreting effector cytokines that act on other immune cells

However, excessive caffeine consumption can lead to adverse effects, including addiction, nervousness, irritability, anxiety, tremors, muscle twitching, insomnia, and heart palpitations (160)

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More than 20% of patients experienced grade 3 adverse events (AEs), including febrile neutropenia (47%, 23/49), thrombocytopenia (37%, 18/49), leukopenia (25%, 12/49), and anemia (22%, 11/49)