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Furthermore, sensitivity analysis 27 , I 2 statistic and Cochrane Q test 28 , meta-regressions 29 , and Eggers test 30 were performed as previously described

Circulating UA is distributed via the bloodstream to excretory organs (kidneys and intestines) for elimination (Hille et al., 2014

The treatment with biomimetic HAP showed statistically significant skin roughness reduction, skin elasticity and firmness increases (results summarized in figure 3)

This direct delivery bypasses the skin barrier, which can limit the absorption of topically applied ingredients, ensuring more consistent and potent therapeutic levels