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Discussion Metabolic comorbidities have been identified as key risk factors for COVID-19 severity and mortality 5,69

7.2 Polyphenols: orchestrators of redox balance and metabolic homeostasis Polyphenols mitigate ALD by chelating iron to block Fenton reaction-driven hydroxyl radical generation, while epigenetic modulation through SIRT1-mediated deacetylation of NF-B and histones further suppresses inflammation (Song et al., 2020)

Thus, upon identification of circulating IgG auto-Abs, FcRn antagonists may be applied as either a prophylactic strategy or as a therapeutic intervention to treat such disorders once they appear