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The signs and symptoms of vitamin B12 deficiency may include: fatigue difficulty thinking and remembering infertility heart palpitations pale skin dementia weight loss numbness and tingling in the hands and feet mood changes constipation a sore tongue low appetite Many people are unclear about precisely what these vitamins do despite vitamin B12 being so important for the bodys healthy function

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Second, the hypoxic environment of the periodontal pocket directly upregulates expression of the fatty acid transporter CD36 via HIF-1, increasing cellular uptake of extracellular fatty acids and providing a more abundant substrate for ACSL4 (25, 26)

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