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This process is initiated when an action potential arrives at the presynaptic terminal of a neuron, triggering the opening of voltage-gated calcium channels

In this study, researchers investigated microglial activation and distribution in high-functioning autistic adults

These observations support a model of APR-246 activity in which cell death is induced via various mechanisms in both p53-dependent and p53-independent manners

Moreover, generation of oxygen-free radicals, e.g., the hydroxyl radical and then hydrogen peroxide, resulting from redox cycling of 4-OHE 2 to the E 2 3,4Q and back conversion to 4-OHE 2 , lead to oxidative modification of DNA