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Endothelial dysfunction impairs cutaneous microvascular blood flow by inducing an imbalance between vasorelaxation and vasoconstriction as a consequence of reduced nitric oxide (NO) production and the increase of oxidative stress and inflammation

Possible effects depend on the exact medication but may include: Pain, redness, itching, or swelling at the injection site Headache Fatigue Nausea or digestive symptoms Dizziness Changes in appetite Fluid retention Changes in blood sugar Changes in heart rate or blood pressure Hormonal effects Allergic or immune reactions For many newer peptides, the full side-effect profile and long-term risks are not known