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The evidence supporting its use includes retrospective data showing pain improvements in EDS, specific studies like those on TMJ hypermobility, and extensive anecdotal successes in practice

Additionally, the ROC curve study demonstrated the precision of the risk model in forecasting PFS over 1, 3, and 5 years, emphasizing its potential clinical application (Figure 2 E)

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Our findings provide direct supportive experimental evidence supporting that PQQ might have anti-aging effects due to its antioxidant role