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Description

PFS, Progression free survival

De-Paula VJ, Gattaz WF, Forlenza OV

DOI: 10.3969/j.issn.1673-5374.2012.05.009 11

The pKa of the lipid is an important factor as the lipid needs to be positively charged at low pH in the LNP to bind RNA but uncharged at neutral pH so the LNP does not cause toxicity