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In this way, it seems that although the three human isoforms of superoxide dismutase (SOD), copper/zinc (Cu/Zn)-SOD, manganese (Mn)-SOD, and extracellular (EC)-SOD, form the primary endogenous defense against oxidative stress, their expression levels and cellular localization in IBD mucosa might be controversial

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This blog represents my honest assessment as a physician navigating this emerging space, with all its promise and its very real limitations

We showed that the GCLC mRNA expression level was downregulated by ACTL6A KD and was upregulated when ACTL6A was overexpressed, but the GCLM expression was not changed (Supplementary Fig 5a, b)