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In this respect, it is plausible that autoimmune responses, which play a role in chronic fatigue syndrome and depression [28, 119] and Long COVID [120], and pulmonary fibrosis with scarring and cardiac remodeling [71] contribute to neuropsychiatric symptoms

ALS pathogenic mutations identified in RNA-binding proteins (RBPs) include TAR DNA binding protein 43 (TDP-43), fused-in-sarcoma (FUS), Ewing sarcoma (EWS), TATA-binding protein-associated factor 15 (TAF15), and heterogeneous nuclear ribonucleoproteins (hnRNPs) 5,6