glutathione have free radicals Figure 1 from in the physiological control of cell function Frontiers | Glutathione: A Samsonian

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Indeed, unlike other thiols, homocysteine incubation with endothelial cells induces an increased expression of the stress protein GRP78 and a decreased expression of glutathione peroxidase, a major intracellular antioxidant enzyme, through a mechanism that depends on an alteration of the intracellular redox potential (Kokame et al, 1996

The imbalance between oxidative and antioxidant causes the internal environment in which neurons live to be compromised, affecting substances such as lipids, proteins and nucleic acids in neuronal cells, and affecting neuronal structure as well as function

J Am Soc Nephrol 25:623633