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Its not out there, surprisingly, all the space is downwards

This process takes place in drugs which contain aromatic rings in their structures

10.1038/nature14344 27 JiangT.ChengH.SuJ.WangX.WangQ.ChuJ.et al (2020)

2.4 Changes in drug targets Thymidylate synthase (TS), the target of 5-FU, was overexpressed in 5-FU-resistant HCT116 colon cancer cells and associated with poor survival (48)