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Apart from proliferative effects, Nrf2 activation enhances antioxidative enzymes, which counteracts ROS-mediated cell death

Disruption of redox homeostasis in the central nervous system is implicated in the pathogenesis of MS

20 Other antibody-associated (often paraneoplastic) neurologic disorders exist that can present with pervasive dysautonomia, often in the setting of severe nervous system dysfunction

Normal luminal bacteria, especially bacteroides species, mediate chronic colitis, gastritis, and arthritis in hla-B27/Human Beta2 microglobulin transgenic rats