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doi: 10.1016/j.ijbiomac.2023.124930 10 ChenO.DengL.RuanC.YiL.ZengK

However, an /-fold hydrolase EH subfamily categorizes mEH, sEH, EH3, and EH4 together from the remaining three EHs (which can be categorized separately based on their catalytic mechanism and substrate preferences) ( 4.3.1 sEH Overall, mEH and sEH have received significantly more attention than EPHX3/4 and thus, their functions are better understood

Given that the ingredients of TCM pharmacotherapies are complex, clarifying their acting mechanisms is a necessary stepping stone to transfer TCM from evidence-based to mechanism-based

Elevated levels of cleaved PARP are associated with HSC apoptosis, which can be induced by pharmacological agents such as berberine (BBR) and carvedilol (89,90)