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20 NRF2 was first identified in 1994, 21 and by 1996, 22 it had been discovered that under oxidative stress conditions, it could activate the expression of antioxidative enzyme genes, including NQO1, GPX4, TXN, and PRDX1

Food and Drug Administration no longer requires that drugs are tested in animal models if they have been tested in cell-based assays, organ chips or microphysiological systems