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Androgens are not major down-regulators of androgen receptor levels during growth of the immature rat penis

Its activity intersects two major metabolic pathways simultaneously: the NAD+ biosynthesis pathway (by consuming nicotinamide, an NAD+ precursor, NNMT competes with the NAD+ salvage pathway) and the methyl-donor pathway (by consuming SAM, NNMT reduces the availability of methyl groups for epigenetic and metabolic methylation reactions)

"Anaerobic synthesis of vitamin B12: characterization of the early steps in the pathway" (PDF)

Weight loss becomes noticeable around week 8-12, averaging 1-2 pounds weekly once you reach maintenance dose