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Phosphoinositides, major actors in membrane trafficking and lipid signaling pathways

Necroptosis, characterized by necrotic cell morphology, is generally viewed as an uncontrolled process leading to plasma membrane rupture and swelling of organelles (Lin et al

The immune cells contribute to angiogenesis via secreting pro-angiogenic factors

These findings add to the model that FRDA is a disease of production of oxidative stress, suggesting that FRDA is a disease also of deficient response to oxidative stress