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Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma

Cytochrome P450 (CYP) enzymes activate the xenobiotic making it more reactive, while the Glutathione S -transferases (GST) enzymes conjugate the reduced glutathione with electrophilic compounds, facilitating the toxic products excretion