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Glutathione helps to maintain normal immune system function, and has antioxidant and integrative detoxification effects 43

Instead, the disease and context specific loss or disruption of astrocyte functions can result in the accumulation of various potentially toxic metabolites or in the loss of support functions for neurones or synapses or in (the deadliest) combination of both

DP2, D prostanoid receptor 2

Co-cultures were stimulated with 50 ng/mL phorbol-12-myristate-13-acetate (PMA) and 750 ng/mL ionomycin (both Sigma-Aldrich) for 4 h in the presence of 2 M monensin (Biolegend) at 37 C and 5% CO 2 /95% humidified air