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Despite this, the anti-tumor efficacy of PLD is still limited due to low stability, insufficient availability, or uncontrolled and inadequate release of the encapsulated drug at the tumor site 6,7

Nevertheless, patients should be aware of a small risk of transmitting generalized disease to their descendents.28,30 It is important to highlight that gonadal mosaicism is independent of the site of the affected cutaneous area, which is not necessarily localized on or near the gonadal region

As long as weight loss has slowed (entering a maintenance phase or losing at a moderate rate), nutritional status is optimized, and no other correctable factors are driving the shedding, hair can recover even while continuing therapy