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Discussion The main goal of this study was to employ network pharmacology to identify the connecting links between epilepsy, antiseizure medications (ASMs) and oxidative stress, in an attempt to pinpoint specific oxidative stress pathway components which may possess the potential to be targeted in epilepsy therapy

Forkhead box protein O4 (FOXO4) is an anti-apoptotic transcription factor which is upregulated in some senescent cells and prevents cell death by sequestering the nuclear protein p53 (70)

These considerations play a pivotal role in answering the question, Is clonidine a controlled substance ? such as: Potential for abuse: This refers to the likelihood of someone misusing the drug to experience a pleasurable effect or to achieve a sense of euphoria

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