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Gastrointestinal adverse events were mostly mild, transient, and occurred during dose escalation, with only one participant discontinuing treatment due to gastrointestinal symptoms after the third dose

Multiple phosphorylation sites have been identified on both ER and ER 81,82 , supporting this hypothesis, though these sites have yet to be reported in zebrafish

Although we excluded patients with hepatic cirrhosis from this study, liver-produced IGF-1 can be affected by the conditions of nonalcoholic fatty liver disease 39,40