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Moreover, encapsulating mRNA encoding tumor-specific toxic proteins neutrophil elastase (ELANE) or porcine pancreatic elastase (PPE) in lipid nanoparticles to form ELANE or PPE mRNA-LNP can both induce CD8 + T cell infiltration and significantly inhibit tumor growth (148)

Cell 89 , 275285 (1997)

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The redox homeostasis that protects from oxidative stress will be enhanced by more glutamate synthesis from glutamine, and more reductive glutamine metabolism promotes lipid biosynthesis that promotes HCC proliferation