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Stephen Thomas, director of the Upstate Global Health Institute and a professor of microbiology and immunology who specializes in infectious disease

In AD and other tauopathies, these chaperones modulate tau homeostasis by preventing aggregation of hyperphosphorylated tau species and promoting their degradation

Jun 2018;3(2):76-83

Ageing has been associated with various metabolomic profiles including elevated isoleucine, acetylcarnitine, pipecolate, methionine, glutarylcarnitine, 5-hydroxytryptophan, ketoleucine, and hippurate with decreased methylthioadenosine and 3-methyladenine 43 , markers of the carnitine shuttle, sucrose, biopterin, vitamin E metabolism, tryptophan, and tyrosine 44 and elevated cysteine, pantothenic acid, 5-hydroxyindoleacetic acid (5-HIAA), aspartic acid, and glutamate and reduced asparagine and glycerophosphocholine 45