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In fact, CD38 knockout mice exhibit significant increases in both extra- and intracellular NAD + levels ( Because of its ability to use NAD + as a substrate, CD38 has been hypothesized to act as a metabolic sensor, limiting the duration of NAD + half-life and signaling in the extracellular compartment

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Despite the role of amino acids in protein synthesis, another important aspect is mitochondrial homeostasis due to the close interaction between amino acid metabolism and mitochondria

Other than that, it was in 2010