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Niraparib maintenance therapy using an individualised starting dose in patients with platinum-sensitive recurrent ovarian cancer (NORA): final overall survival analysis of a phase 3 randomised, placebo-controlled trial

Both decreased and increased apoptosis can lead to pathological changes

The broader message is simple: more is not always better

To test the feasibility of using Cys and its oxidized species as a measure of oxidative stress, we developed a high-throughput quantitative assay for the simultaneous analysis of a panel of small-molecule thiols and disulfides by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) using multiple reaction monitoring (MRM) coupled with stable isotope dilution