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Additionally, 1,8-diMQ and 5-amino-1MQ showed little inhibition of COMT at maximal tested concentrations of 200 M (20% inhibition) and 600 M (10% inhibition), respectively, although no clear trend of concentration-dependent inhibition was observed

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A 2015 rabbit osteoarthritis model found that intra-articular injection of AOD-9604, particularly combined with hyaluronic acid, improved cartilage integrity and reduced joint degradation

This matters for dosing because beta-3 receptor sensitivity varies throughout the day and in response to nutritional status