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For LTP, repetitive and strong depolarization of the neurons allows significant influx of Ca 2+ into the cytoplasm and activation of protein kinases, including the calcium/calmodulin-dependent protein kinase II (CaMKII), which (a) phosphorylate and activate AMPA-Rs and (b) trigger the insertion of additional AMPA-Rs into the postsynaptic membrane [35]

I know that this can be hard to do, as each surgery and successive surgeon tells you they can fix your wrist, but the earlier you step back and look for non-surgical alternatives, the better

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