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Modulating microglial polarizationby suppressing pro-inflammatory M1 phenotypes or promoting neuroprotective M2 states is increasingly recognized as a strategy to mitigate neuroinflammation in PD, wherein, BL may play a role in facilitating this phenotypic shift (Yin et al., 2022)

Specifically, -hydroxybutyrate can effectively inhibit the activation of the NLRP3 inflammasome, and preclinical studies have demonstrated its ability to reduce BBB permeability (133)

These advantages have linked some polyphenols, such as resveratrol, quercetin, and curcumin, to muscle health (551)

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