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Even if we do not treat this topic, the interaction between Met, Cys and selenium (Se) species coming from diet or intracellular metabolism, represents another big chapter in S biology: seleno-Met leads to the formation of selenide species, the co-substrate of the enzyme seleno-Cys synthase ( Figure 2 - 27, 28) , an enzyme able to transform Ser-tRNA into seleno-Cys-tRNA, this last incorporated into selenoproteins

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These findings suggest that cuproptosis activators can stabilize NFE2L2 protein, activating it in PDAC cells