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The peptide received FDA approval in June 2019 under the brand name Vyleesi for treatment of acquired, generalized hypoactive sexual desire disorder in premenopausal women, establishing it as a first-in-class medication with a novel mechanism distinct from all previous sexual dysfunction treatments

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Factors such as initial B12 levels, underlying medical conditions, certain medications, advanced age, and injection frequency can affect the absorption and utilization of B12, possibly shortening the duration of action

These samples were dried, reconstituted in 20 l of loading buffer (0.1% TFA, 1% acetonitrile), and stored at 20C for subsequent mass spectrometry (MS) analysis