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Glas J, Torok HP, Tonenchi L, Muller-Myhsok B, Mussack T, Wetzke M et al

These are the most common early knee osteoarthritis symptoms: Pain that worsens when youre active but eases with rest Pain that worsens if you need to bend your knee over and over, like when going up stairs Over time, you might experience: A feeling like your knee wont support you as you stand or walk (may feel wobbly) Swelling Stiffness in the knee, especially in the morning or when you have been sitting for a while Less mobility of the knee, making it hard to get in and out of chairs or cars, use the stairs, or walk A feeling like your knee is locking up, getting stuck, and wont move how you want it to move A creaking, crackly sound when you move your knee How Is Osteoarthritis of the Knee Diagnosed

doi: 10.1158/1535-7163.MCT-14-1078

Blood 100:10481054 Batra S, Sabnis YA, Rosenthal PJ, Avery MA (2003) A structure-based approach to falcipain-2 inhibitors: synthesis and biological evaluation of 1,6,7-trisubstituted dihydro isoquinolines and isoquinolines