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Int J Nanomed, 2024, Vol 19, pp 17671807

In the foundational 1996 dose-ranging study in healthy elderly subjects, oral MK-677 increased 24-hour GH concentrations in a dose-dependent manner roughly doubling mean GH at the 25 mg dose and the researchers attributed this to an enhancement of pre-existing pulsatile GH secretion : pulse height and interpulse nadir concentrations rose, while the number of pulses did not change significantly

Suzuki K, Doki K, Homma M, Tamaki H, Hori S, Ohtani H, Sawada Y, Kohda Y (2009) Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy